Valerie AMSELLEM

Je suis actuellement en post-doc a londres dans un laboratoire public affilie a imperial college. Dans le cadre de ce post-doc, j'etudie les voies de signalisation dependantes de la proteine ICAM-2 dans la formation de junction, migration et angiogenese.

Degree diploma

1998-1999 Master’s degree in science, biochemistry speciality (university PARIS VI)

1999-2000 Post graduate degree (B), Museum national d’histoire naturelle : Activités biologiques des substances naturelles. Reconnaissance moléculaire et communications cellulaires.

2000-2004 Ph.D at doctoral cancerology school Biology, Medicine, Health (university PARIS XI) directed by T.TURSZ and C.AUCLAIR

Source of funding
2006(oct)-2008(sept) British heart fundation (BHF) grant
2004(oct)-2006 (sept) European FP6 grant
2003-2004 (sept) : 12 month “ligue contre le cancer” association scholarships
2000-2003 Ministry scholarships

Current post
Post-doctoral research fellow in BHF cardiovascular Medicine unit, Imperial College based at Hammersmith Hospital du Cane road, London directed by Pr Dorian Haskard. Role of ICAM-2-dependent signalling in endothelial junction assembly, migration and angiogenesis directed by Dr A.Randi and funded by British heart fondation.

oct 2004-oct 2006
Post-doctoral research fellow in BHF cardiovascular Medicine unit, Imperial College based at Hammersmith Hospital du Cane road, London directed by Pr Dorian Haskard. Role of ICAM-2-dependent signalling in endothelial junction assembly, migration and angiogenesis directed by Dr A.Randi and funded by Network excellence on targeting Cell Migration in Chronic Inflammation.

Last professional experience

January to september 2000 : 9 month at Institute Gustave Roussy in laboratory CNRS UMR 8532 directed by Pr C.AUCLAIR. Role of zyxin in transformation induce by EWS FLI-1 oncoprotein directed by Dr F.SUBRA.

October 2000- september 2004 : Ph.D at Institute Gustave Roussy in laboratory CNRS UMR 8532 directed by Pr C.AUCLAIR. Role of zyxin in tumoral suppressor effect in Ewing tumor cells.

Publication

V.Amsellem, M.H Kryszke, M.Hervy, F.Subra, R.Athman, H. Leh, C. Brachet-Ducos and C.Auclair
The actin cytoskeleton-associated protein zyxin acts as a tumor suppressor in Ewing tumor cells.
Experimental Cell Research 304(2005)443-456

Miao-Tzu Huang, Justin C Mason, Greame M Birdsey, Valerie Amsellem, Nicole Gerwin, Dorian O Haskard, Anne J Ridley and Anna M Randi. Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis. In revision on Blood in April 2005

Patent

V.Amsellem, M.Hervy, F.Subra, C.Auclair.Bioalliance Pharma, ENS Cachan, Institute Gustave Roussy and CNRS. Composition containing agent that stabilizes the actin network of the cytoskeleton, useful for treatment, prevention and diagnosis of tumors
WO 02/102846A2 available on line : http://fr.espacenet.com/espacenet/fr/fr/e_net.htm



PS :Renouvellement de contrat oct 2006-sept2008. Puis retour en france pour travailler en insdustrie pharmaceutique en tant que R etD ou bien passer les concours public CR2-CR1.

Secteur : Pharmacie et santé

Secteur : Pharmacie et santé