Olga Kouessi

Formulation of inhalation drug products

Sector: Pharmaceutical

*Management of Research & Development projects
Elaborated the specifications.
Conceived products adhering to specifications.
Managed a team of junior engineers and technicians.
Checked the formulations: sensory analysis, stability studies.
Improved the existing products :
- extended the best before date,
- reduced fat separation for paste products,
- increased fat protection,
Validated new raw materials and suppliers,
Validated formulas for manufacturing,
Released finished products batches.
Coordinated studies with external Research partners, suppliers, Marketing et Manufacturing departments.
Ensured compliance with regulations: European law, Codex alimentarius, cGMP.
Technological watch.

*Communication
Wrote arguments for customers.
Managed the returns.

*Techniques
-Formulation and innovation :
Innovative products: highly nutrient-dense spreads or powders fortified with vitamins and minerals, dispersible tablets, film-coated tablets, granulates, microcapsules, microspheres, emulsions, suspensions.
-Optimisation of the use of ingredients and additives for texture, flavour, colour and stabilize.
-Characterization :
Laser granulometry, sieving, powder rheology, fat oxidation, thermal analysis, UV-visible spectroscopy, Zeta potential measurement, HPLC, strain measurement.

Sector: Agribusiness and agriculture

Mission:
Tablets film coating optimisation, for upscale purpose, to solve a lack of adhesiveness

Results:
- found out the critical factors of the process in order to reduce moisture content in the coater,
- found out spray conditions to obtain a uniform spray distribution,
- advised the use of a seal coating method, two-phases process, in very dry conditions,
- optimised the first phase of the process.

Sector: Pharmaceutical

Performed bacteriology, hematology and immunology analysis.

Sector: Health and pharmaceutical

Studied phenol degrading bacteria isolated from an activated sludge :
- selected phenol degrading strains with optical density measurements,
- extracted chromosomal and plasmid DNA and electrophoresis characterization,
- designed degenerate primers with multiple sequence alignment of various phenol
hydroxylases sequences,
- amplified some gene fragments by PCR.

Sector: Universities and higher education institutions