Jérémie Vitte

Research about Parkinson's disease:
· Characterization of the cellular and subcellular distribution of LRRK2 protein in normal or pathogenic human brain.
· Characterization of neuronal damage in an alpha-synuclein mouse model.

http://www.u289.ifrns.chups.jussieu.fr/fr/

Sector: Health and pharmaceutical

INSERM (French National Institute for Health and Medical Research)

Managed several projects aiming at understanding the physiopathology of Spinal Muscular Atrophy (SMA), a neuromuscular disease characterized by degeneration of lower motor neurons. Acquired experience in project management, lab techniques and communication skills.

• Molecular and histological characterization of a new mouse model for SMA.
• Study of SMN protein isoforms in human cell lines and tissues and in cell cultures (cell lines and primary cultures). Characterization of new antibodies and transfection experiments.

Participation to international meetings.

Keywords: SMA, SMN, cellular and mouse models, neuromuscular system.

Main publications:
www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17717146&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15509541&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Sector: Health and pharmaceutical

CHRU (Teaching Hospital)

Studied the subcellular localization of a transcription factor implicated in leukemia.

• Immunocytochemistry on cells from patients or cellular culture.

Keywords: STAT5b, K562 cells, CML, subcellular localization, nucleoli.

Sector: Health and pharmaceutical