International Senior scientist, Pfizer PGRD, Sandwich (UK), since January 2004
• Senior scientist, Discovery Biology Department, since June 2005
- Project management
- Lead compounds pharmacological characterisation
- Cell line generation compatible for HTS
- Molecular and Biochemical assay development
- Functional assay development
- People supervision
• GPCR Biochemist, Structural Biology Department, January 2004 – May 2005
- Assumed scientific leadership role for the GPCR Initiative
- Developed and implemented a strategy for the production of GPCRs
- Developed people and organised the work inside the multidisciplinary team
- Aided in the prosecution and development of GPCRs solubilisation and purification
- Built strong links with leading external academic groups.
1 contact
Benedicte Perret
Senior scientist, Pfizer
Ramsgate - United Kingdom
| English | French |
Schools attended |
Université Strasbourg 1 Louis Pasteur (PhD in Molecular and Cellular Biology) |
Ecole Normale Supérieure (Magistère de Biologie) |
1999 - 2003 : CNRS |
PhD
| |
PhD, Receptors and Membrane proteins Department, CNRS UPR9050, (now ESBS UMR 7175), Strasbourg (France) 2000- 2003, Franc Pattus' group - Developed the overexpression and purification of stable GPCR in various insect cell systems combining molecular biology, cellular biology, in vitro pharmacology and biochemistry approaches - Implemented and developed the drosophila expression system to produce large amount of receptors - Used fluorescence technology to develop an innovative method to assess the activity of the receptor through all the process from the expression to the purification - Responsible for the set-up and management of international collaborations - Managed a technician Perret B G, Wagner R, Lecat S, Brillet K, Rabut G, Bucher B and Pattus F, "Expression of EGFP-aminotagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors", 2003, Protein Expression and Purification, 31, pp 123-132 | |
Sector: Research and development |